ABSTRACT
The title has been spelled incorrectly: "MEALS" should have appeared as "MELAS".
ABSTRACT
Myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) is a multisystem clinical syndrome manifested by mitochondrial myopathy, encephalopathy, lactic acidosis and recurrent stroke-like episodes. A 27-year-old female with MELAS syndrome presented with cerebral infarction. Echocardiography revealed a thrombus attached to the apex of the hypertrophied left ventricle, with decreased systolic function. The embolism of the intracardiac thrombus might have been the cause of stroke. There should be more consideration given to the increased possibility of intracardiac thrombus formation when a MELAS patient with cardiac involvement is encountered.
Subject(s)
Female , Humans , Acidosis, Lactic , Cerebral Infarction , Echocardiography , Embolism , Heart , Heart Ventricles , MELAS Syndrome , Mitochondrial Myopathies , Muscular Diseases , Stroke , ThrombosisABSTRACT
Polymyositis is characterized by symmetrical proximal muscle weakness, nonsuppurative inflammation of skeletal muscle, elevation of muscle enzyme levels, and abnormality of electromyographical change. Its pathogenesis is unclear. Paraneoplastic syndromes are caused by malignant tumors, although not through direct effects of the primary tumor or its metastases. Several paraneoplastic syndromes, including erythrocytosis, hypoglycemia, and hypercholesterolemia, have been reported in patients with hepatocellular carcinoma. A few cases of polymyositis associated with hepatocellular carcinoma and one case of combined hepatocellular-cholangiocarcinoma associated with polymyositis and chronic hepatitis B virus infection have been reported. Skeletal muscle injuries without trauma, including metabolic myopathy, effects of certain drugs and toxins, infection, electrolyte imbalances, and endocrine disorders, may cause rhabdomyolysis. We present here a case of primary liver cancer associated with polymyositis and rhabdomyolysis.
Subject(s)
Humans , Carcinoma, Hepatocellular , Hepatitis B, Chronic , Hypercholesterolemia , Hypoglycemia , Inflammation , Liver , Liver Neoplasms , Muscle Weakness , Muscle, Skeletal , Muscles , Muscular Diseases , Neoplasm Metastasis , Paraneoplastic Syndromes , Polycythemia , Polymyositis , Rhabdomyolysis , VirusesABSTRACT
Polymyositis is characterized by symmetrical proximal muscle weakness, nonsuppurative inflammation of skeletal muscle, elevation of muscle enzyme levels, and abnormality of electromyographical change. Its pathogenesis is unclear. Paraneoplastic syndromes are caused by malignant tumors, although not through direct effects of the primary tumor or its metastases. Several paraneoplastic syndromes, including erythrocytosis, hypoglycemia, and hypercholesterolemia, have been reported in patients with hepatocellular carcinoma. A few cases of polymyositis associated with hepatocellular carcinoma and one case of combined hepatocellular-cholangiocarcinoma associated with polymyositis and chronic hepatitis B virus infection have been reported. Skeletal muscle injuries without trauma, including metabolic myopathy, effects of certain drugs and toxins, infection, electrolyte imbalances, and endocrine disorders, may cause rhabdomyolysis. We present here a case of primary liver cancer associated with polymyositis and rhabdomyolysis.
Subject(s)
Humans , Carcinoma, Hepatocellular , Hepatitis B, Chronic , Hypercholesterolemia , Hypoglycemia , Inflammation , Liver , Liver Neoplasms , Muscle Weakness , Muscle, Skeletal , Muscles , Muscular Diseases , Neoplasm Metastasis , Paraneoplastic Syndromes , Polycythemia , Polymyositis , Rhabdomyolysis , VirusesABSTRACT
Cogan's syndrome is a rare systemic inflammatory disease and can be diagnosed on the basis of typical inner ear and ocular involvement with the presence of large vessel vasculitis. We report a case of Cogan's syndrome with stable angina resulting from coronary ostial stenosis caused by aortitis.
Subject(s)
Angina Pectoris , Angina, Stable , Aortitis , Cogan Syndrome , Constriction, Pathologic , Ear, Inner , Glycosaminoglycans , VasculitisABSTRACT
Coronary vasospasm plays an important role in the pathogenesis not only of variant angina, but also of ischemic heart disease in general, including other forms of angina pectoris, acute myocardial infarction, and sudden death. Vasoactive events leading to an acute reduction in regional myocardial flow in the presence of a normal or previously compromised circulation are a common cause of arrhythmias. However, coronary vasospasm-induced electrical and mechanical complications are rarely reported in patients with angiographically normal or near-normal coronary arteries. This paper presents our experience with a patient presenting with coronary vasospasm-associated ventricular fibrillation without findings of significant coronary artery disease.
Subject(s)
Humans , Angina Pectoris , Angina Pectoris, Variant , Arrhythmias, Cardiac , Coronary Artery Disease , Coronary Vasospasm , Coronary Vessels , Death, Sudden , Myocardial Infarction , Myocardial Ischemia , Ventricular FibrillationABSTRACT
Coronary vasospasm plays an important role in the pathogenesis not only of variant angina, but also of ischemic heart disease in general, including other forms of angina pectoris, acute myocardial infarction, and sudden death. Vasoactive events leading to an acute reduction in regional myocardial flow in the presence of a normal or previously compromised circulation are a common cause of arrhythmias. However, coronary vasospasm-induced electrical and mechanical complications are rarely reported in patients with angiographically normal or near-normal coronary arteries. This paper presents our experience with a patient presenting with coronary vasospasm-associated ventricular fibrillation without findings of significant coronary artery disease.